![]() The final genome assembly was deposited in GenBank with identifier MPXV-INMI-Pt1 and contains 190,280 nucleotides with a mean coverage of 159 reads. All reads were mapped to the genome, and all variants were manually curated. Major contigs were aligned to a German monkeypox sequence ( GenBank ON568298.1) and then manually reviewed. Metagenomic sequencing was performed using an Ion Torrent GeneStudio S5 system. Italy’s first available monkeypox genome was released on May 26, 2022, using DNA extracted from a scab sample from this case ( GenBank ON614676.1). The first monkeypox case in Italy was reported on May 18, 2022, from a 39-year-old Italian man returning from the Grand Canary Islands. To date, over 100 monkeypox genomes have been deposited GenBank 2, including a genome sequenced with Ion Torrent next-generation sequencing from the first Italian monkeypox case 3. Researchers are now using genomic sequencing to investigate the spread and evolution of the monkeypox virus by tracking mutations across its ~197,000 nucleotide DNA sequence. However, in 2022, a global monkeypox outbreak caused alarm with a rapid rise in cases in at least 50 counties 1. The monkeypox* virus is a member of the smallpox family and is currently endemic to western and central Africa. ![]()
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